ELFT HÍRADÓ

[Király Beáta <kiraly.beata AT atomki.hu>]

The production of Palladium-103 Auger-emitting radionuclides for targeted 
cancer therapy 



by Laouameria Nour Aicha (HUN-REN ATOMKI) 



When: 2024-03-28 Thursday 11:00 AM 


Where: HUN-REN ATOMKI, visitor center (Debrecen, Bem tér 18/c) 





Additional information: 
- Tea and cookies are offered before the seminar at 10:30 AM. 
- One of the authors presents the [ https://atomki.hu/articles/current | 
paper of the month ] 2024/2: 



Innovative approach to producing Palladium-103 for Auger-emitting 
radionuclide therapy: a proof-of-concept study, [ 
https://doi.org/10.3390/ph17020253 | Pharmaceuticals 17:2 Paper:253, 13 p. 
(2024) ] . 








Abstract: 




Auger-emitting radionuclides, exemplified by Pd-103, exhibit considerable 
therapeutic potential in cancer treatment due to their high cytotoxicity and 
localized biological impact. Despite these advantages, the separation of such 
radionuclides presents a complicated challenge, requiring intricate and 
time-intensive “wet chemistry” methods attributed to the exceptional chemical 
inertness of the associated metals. Our study proposes an innovative solution 
to this separation challenge through the design and implementation of a 
radionuclide separation equipment (RSE). The equipment employs a dry 
distillation approach, capitalizing on differences in partial vapor pressures 
between irradiated and resulting radioactive metals, with a diffusion-driven 
extraction method applied to separate Pd-103 radionuclides generated via the 
proton irradiation of Rh-103 at cyclotron. 




--- 
Király Beáta, PhD 
HUN-REN ATOMKI / HUN-REN Atommagkutató Intézet 
C: 4026 Debrecen, Bem tér 18/c 
T: +36 52 509 200 
E: kiraly.beata AT atomki.hu 
W: [ http://www.atomki.hu/ | www.atomki.hu ]