ELFT HÍRADÓ

[Horváth Zsolt Endre <horvath.zsolt.endre AT ek-cer.hu>]

Kedves Kollégák!


Figyelem, a szokásostól eltérő időpont!!!

2023 február 2-án, csütörtökön 10 órakor az MFA tanácstermében (KFKI 26. 
épület 1. emelet) kerül sor

Kásás Sándor
(Laboratoire de Physique de la Matière Vivante, EPFL, CH-1015 Lausanne, 
Switzerland és
Unité Facultaire d’Anatomie et de Morphologie, CUMRL, Université de 
Lausanne, Switzerland)

Nanomotion based antibiotic sensitivity test

c. előadására.

Abstract

Fiveyears ago we noticed that attaching living organisms onto an atomic 
force microscope (AFM) cantilever permits to detect oscillations that 
can be used to assess the organism metabolic state or its life-death 
transitions in a label free manner. The technique relies on the fact 
that all living organisms oscillate at a nanometric scale as long they 
are alive and stop these movements as soon they die. The oscillations 
are easily detected with commercially available AFMs or with homemade 
dedicated instruments. Typical experiment consist in attaching the 
organism of interest onto an AFM cantilevers and inserting it into the 
analysis chamber of the instrument. A dedicated electronics monitors the 
oscillations of the lever for about 15 minutes and eventually a drug 
that modifies the organism’s metabolism is injected into the analysis 
chamber. The modifications occurring in the oscillation pattern before 
and after the injection assess the action of the drug. We successfully 
tested the technique on bacteria, yeast, vegetal and animal cells. We 
are therefore confident that AFM based nanomotion detection offers novel 
avenues to explore living organisms in a label free and chemistry 
independent manner. During the presentation, numerous examples of 
nanomotion detection will be presented and the potential applications of 
the technique in microbiology, medicine and astrobiology will be discussed.

A szemináriumon minden érdeklődőt szívesen látunk!

Horváth Zsolt Endre
Szeminárium koordinátor

--
Dr. Zsolt E. HORVÁTH
Institute for Technical Physics and Materials Science,
Centre for Energy Research
Hungarian Academy of Sciences
(MTA EK MFA)
Konkoly Thege Rd. 29-33, 1121 Budapest,
Mail: P.O.Box 49, H-1525 Budapest, Hungary
Phone: +36-1-392-2680, Fax: +36-1-392-2226
e-mail:horvath.zsolt.endre AT ek-cer.hu  
<mailto:horvath.zsolt.endre AT energia.mta.hu>