ELFT HÍRADÓ

[Balazs Dora <dora.balazs AT ttk.bme.hu>]

                    MEGHÍVÓ



   a Szilárd Leó Kollokvium előadására:


                Szöllősi J. Gergely
                       (ELTE)


/
/
/"/Trade-off between reducing mutational accumulation and increasing 
commitment to differentiation determines tissue organization"


Kivonat: Species-specific differences control cancer risk across orders 
of magnitude variation in body size and lifespan, e.g., by varying the 
copy numbers of tumor suppressor genes. It is unclear, however, how 
different tissues within an organism can control somatic evolution 
despite being subject to markedly different constraints, but sharing the 
same genome. Hierarchical differentiation, characteristic of 
self-renewing tissues, can restrain somatic evolution both by limiting 
divisional load, thereby reducing mutation accumulation, and by 
increasing cells’ commitment to differentiation, which can “wash out” 
mutants. Here, we explore the organization of hierarchical tissues that 
have evolved to limit their lifetime incidence of cancer. Estimating the 
likelihood of cancer in the presence of mutations that enhance 
self-proliferation, we demonstrate that a trade-off exists between 
mutation accumulation and the strength of washing out. Our results 
explain differences in the organization of widely different hierarchical 
tissues, such as colon and blood.



Helye: BME Fizikai Intézet, Fizika Tanszék
Budafoki út 8. F-épület, 2. emelet, 13-as terem


Ideje: 2022. április 12. (kedd), 14:30.
Kapunyitás 14.15-től.
Program: http://physics.bme.hu/kollokvium


Minden érdeklődőt szívesen látunk!




Dóra Balázs és Zaránd Gergely