ELFT HÍRADÓ

[Erdelyi Zoltan <zerdelyi AT dragon.unideb.hu>]

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                           Debreceni Egyetem
                       Szilardtest Fizika Tanszek

                              SZEMINARIUM

                                idopont
                                -------
                  2007. majus 21., hetfo,  11:00 ora

                                Helyszin
                                --------
                         Debrecen, Bem ter 18/b.
                       Szilardtest Fizika Tanszek
                              Eloado terem

                                 Program
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        Colloid-chemical background of nanotechnologies in medicine

                             Prof. Zoya Ulberg

                               Director of

                      Institute of Biocolloid Chemistry
                     Ukrainian Academy of Sciences, Kiev


The colloid-chemical aspects of accumulation of gold and silver 
nanoparticles on the surface of microorganism cells, including cancer and 
inflamed cells, has been developed. The affinity of metals to live cells 
is established, and the role of particle's size in the process is cleared. 
The basis of the phenomenon comprises different colloid-chemical and 
biochemical processes like diffusiophoresis of particles to the cell, 
interaction of its double layers and modification of the transmembrane 
potential, and on the last stage- energy-dependent accumulation and 
transmembrane transportation of metal into the cell. The mechanisms of 
these processes as well as the way of their handling are elucidated.

The second direction of our studies was obtaining of nanosized metals (Au, 
Ag, Fe, Cu, Pt) in  cellular structures which play the role of natural 
templates or nanosize reactors with dimensions up to 10 nm. Biopolymers 
(exopolysaccharides) excreted  by cells have been used as reducing agents 
and stabilisers of metal's nano- and microcrystals. The opportunity of 
metal-cell systems to form mesenchymal stem cells is shown. The system 
consists of hydrogel nanoreactor matrixes (cell size 4-10 nm) that contain 
therapeutic doses of metals and that are biocompatible with stem cells 
synthesised in our institute.  The nanometal-cell systems have been 
clinically tested for treatment of different diseases.

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